FIXED COMBINATION DRUGS

About:

• Fixed Dose Combination (FDC) drugs includes two or more active pharmaceutical ingredients (APIs) combined in a single dosage form, which is manufactured and distributed in fixed doses.
  
  
• Common examples of FDCs: Cough syrups Phensedyl and Corex, Vicks Action 500.
  
  

Advantages of FDCs:

• Burden of keeping track of several medications, understanding their various instructions, etc. is reduced which improves patient compliance and therefore improves treatment outcomes.
  
  
• The FDCs are more economic than single ingredient drugs.
  
  
• The manufacturing cost is quite low as compared to the cost of producing separate products
  
  
• Then there is Simpler logistics of distribution.
  
  

Disadvantages of FDCs:

• If an adverse drug reaction occurs from using an FDC, it may be difficult to identify the active ingredient responsible for causing the reaction.
  
  
• If the drugs combination is not appropriate, then it can lead to some patients getting too much of an ingredient and others getting too little. FDCs "limit clinicians' ability to customize dosing regimens."